Recode v. 2.0 / Database of translational recoding events.

 

About

What is Recode2

Recode2 is a database of genes that utilize non-standard translation for gene expression purposes. Recoding events described in the database include programmed ribosomal frameshifting, translational bypassing (aka hopping) and mRNA specific codon redefinition. Frameshifting at a particular site often yields two protein products from one coding sequence and sometimes serves a regulatory purpose by acting as a sensor of the level of product protein or of some external ligand. Bypassing (hopping) allows the coupling of two ORFs separated on an mRNA by a coding gap. Codon redefinition occurs when a stop codon is decoded as a standard amino acid (often glutamine or tryptophan), or the 21st amino acid selenocysteine.
These recoding events are in competition with standard decoding and are site specific. The efficiency of recoding is often modulated by cis-stimulators and sometimes by trans-factors. The sequences of the genes that use recoding for their expression are in the database. The recoding sites and the known stimulatory signals are annotated in the database together with notes on factors that are known to affect recoding efficiencies.
Recode2 does not yet describe certain newly discovered and poorly understood non-standard translation events, such as incorporation of the 22nd amino acid pyrrolysine and StopGo phenomenon.
Recode2 database provides no information on non-standard decoding during gene expression levels other than translation, e.g. due to RNA editing.

Mirrors

Irish mirrorUS mirrorRecode2 mirrors: Irish mirror, US mirror.

Development

recode2
Recode2 was developed by efforts of Michaël Bekaert and Pasha V Baranov.

Recode2 Logo

The new recode logo is a courtesy of Xa0tiK from DeviantArt.

How to contact us

If you have any questions please email Pasha V Baranov or contact:

Dr. Pavel V Baranov
LAPTI, Department of Biochemistry
University College Cork
Cork
Ireland

Google Earth Recode server location

Financial support

SFI
Recode2 development has been supported by SFI grants to Pavel V Baranov and John F Atkins