Recode v. 2.0 / Database of translational recoding events.
Details for "r200065"
| Accession number | r200065 [export] |
| Locus name | dio1 |
| Recode1 name | dio1_s_euk_hsap |
| Description | iodothyronine deiodinase |
| Recode status | Validated |
Organism
| Genomic class | Eukaryota (Chromosome) |
| Organism | Homo sapiens [details] |
Sequence
Recoding event
| Event type | Selenocysteine (position: 382) |
| Description | Selenocysteine incorporation. |
GCCGAGATGG GGCTGCCCCA GCCAGGGCTG TGGCTGAAGA GGCTCTGGGT GCTCTTGGAG GTGGCTGTGC
ATGTGGTCGT GGGTAAAGTG CTTCTGATAT TGTTTCCAGA CAGAGTCAAG CGGAACATCC TGGCCATGGG
CGAGAAGACG GGTATGACCA GGAACCCCCA TTTCAGCCAC GACAACTGGA TACCAACCTT TTTCAGCACC
CAGTATTTCT GGTTCGTCTT GAAGGTCCGT TGGCAGCGAC TAGAGGACAC GACTGAGCTA GGGGGTCTGG
CCCCAAACTG CCCGGTGGTC CGCCTCTCAG GACAGAGGTG CAACATTTGG GAGTTTATGC AAGGTAATAG
GCCACTGGTG CTGAATTTTG GAAGTTGTAC CTGACCTTCA TTTATGTTCA AATTTGACCA GTTCAAGAGG
CTTATTGAAG ACTTTAGTTC CATAGCAGAT TTTCTTGTCA TTTACATTGA AGAAGCACAT GCATCAGATG
GCTGGGCTTT TAAGAACAAC ATGGACATCA GAAATCACCA GAACCTTCAG GATCGCCTGC AGGCAGCCCA
TCTACTGCTG GCCAGGAGCC CCCAGTGCCC TGTGGTGGTG GACACCATGC AGAACCAGAG CAGCCAGCTC
TACGCAGCAC TGCCTGAGAG GCTCTACATA ATCCAGGAGG GCAGGATCCT CTACAAGGGT AAATCTGGCC
CTTGGAACTA CAACCCAGAG GAAGTTCGTG CTGTTCTGGA AAAGCTCCAC AGTTAATCTG GACAGATACC
TCAATTCTAG GTGACCAACG GGAGGGCTTC TCAAGGCTTA GCTCTCCCTG AGACCCAGCT GGCTTTTACC
CTTGACCTGT GTCCCTAGCT GAATCACTAG CTCAGATTTT TCTGATCTAA GCAAACAACT CCCAGCTGAG
GAATGCAGGC CACAGCACCC AATCAAGACA AATTGTTATT ATCAGAAAAT GAAGCAACAC TTGAGCTGTT
CAGGCCAGTT CCCTGTTGAA GAAACAGTTC CCTGTTGAAG AAAGTAGAGC CTGACACTGC TCCCACTTTG
GAGATCACAT TCCCTGCACA CGGTCTTTGA GAGAGCAGTT GCACTCTACA GGCACACTTC TGAGGTACGG
TATCTCTCTC CAGCCACTCT GATACCAAGT AATTCAAGCT GGCATTCCTT CTATTAGGGA AATTCATTTT
ACCCAATTTG CATTTATGGA ATTGATCATT TAAGACACTA AATTAGTTTT TAGAACCAAT TATGGGAAGA
ATTCCAGTTG TTAGGAAGAG ATGAGGAGTT GGAAGAGGAG GGATTAGAAA CAGGAGGAGG CAGTCATCCT
CTCCTTGCCA AAAGATTTAA ACCTGTCCAC ATTGGTGGTG ATGATGGGTG AGTTTCCATG GTAACACATC
CCTAATTTTA CCAGGGAAGA GGAGAGTACT CACTTTACCA TCTTTGAATA TATTTCATAG AAATCTAGCT
CTCTGTACCC TGAAATCTTC CACTAGCCTC ACTTTTCAAC AGAGTCATCT AGAAGGGAGG GTTGGCTTCC
CAAAAGCATA ACCTTGACCA AACCAAACAA TAGGCACCAG CAATGCTGTC ATTCAGTTAT GCAGAAGCTC
ATTTGTGAAA TTCTGTTTCT CTGATTTCTT CGCAAGTCTC TTAATGGTCA TTTGTGTTAG ATTACATCAA
ACTGATGGAT AGCCATTGGT ATTCATCTAT TTTAACTCTG TGTCTTTACA TATTTGTTTA TGATGGCCAC
AGCCTAAAGT ACACACGGCT GTGACTTGAT TCAAAAGAAA ATGTTATAAG ATGCAGTAAA CTAATAACAG
AATTATTAAA ATATATCAGG CTAAAAAAAA GGAACCGCAG GTTCAGACAT TTGGTGTATG TGCTTGGCTG
AGGAGCCAAT GGGGCGAAGC TACCATCTGT GGGATTATGA CTGAACGCCT CTAAGTCAGA ATCCCGCCCA
GGCGGAACGA TACGGCAGCG CCGCGGAGCC TCGGTTGGCC TCGGATAGCC GGTCCCCCGC CTGTCCCCGC
CGGCGGGCCG CCCCCCCCTC CACGCGCCCC GCGCGCGCGG GAGGGCGCGT GCCCCGCCGC GCGCCGGGAC
CGGGGTCCGG TGCGGAGTGC CCTTCGTCCT GGGAAACGGG GCGCGGCCGG AAAGGCGGCC GCCCCCTCGC
CCGTCACGCA CCGCACGTTC GTGGGGAACC TGGCGCTAAA CCATTCCTTT A
Product
| Product | dio1 |
| Description | type I iodothyronine deiodinase; catalyzes 5' deiodination of thyroxine (T4, prohormone) to 3,5,3'-triiodothyronine (T3, active hormone) and of 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2); inactivates T4 and T3 by 5-deiodination; iodohydrolase; oxidoreductase |
| Modifications | 382..384,aa:Sec |
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN WIPTFFSTQY
FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN FGSCTUPSFM FKFDQFKRLI
EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA
ALPERLYIIQ EGRILYKGKS GPWNYNPEEV RAVLEKLHS
Publications
- Walczak R, Westhof E, Carbon P, Krol A. (1996) A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs. RNA. 2(4):367-379. [abstract]
- Mandel SJ, Berry MJ, Kieffer JD, Harney JW, Warne RL, Larsen PR. (1992) Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 75(4):1133-1139. [abstract]