Recode v. 2.0 / Database of translational recoding events.
Details for "r200071"
| Accession number | r200071 [export] |
| Locus name | dio2 |
| Recode1 name | dio2_s_euk_hsap |
| Description | iodothyronine deiodinase |
| Recode status | Reviewed |
Organism
| Genomic class | Eukaryota (Chromosome) |
| Organism | Homo sapiens [details] |
Sequence
Recoding event
| Event type | Selenocysteine (positions: 797, 1196) |
| Description | Selenocysteine incorporation. this gene has alternative transcription sites and alternatively spliced intron in 5'UTR. Presented sequence lacks this intron. |
GCCTGCAGAG AGAGGCACTT TGCACCACAG ACAGATAGCA AGAAGGGAAA GACAGAGAGT GAGAAAAAAG
AGGAGTCAGT CGCTCCTGGG GAAGGGAGAG AGTGAGACTG GGAGAAAGAG AAGCACAGAA AGTGTGTGTA
AAACGGAGTA AAGAAAGAAA AAAAAAAAAC TACCCTTAAA GCACATTTAA AAAAAAAAAA CTCTGGCAAT
TCAAGAAAGA AACAGGCTAC GTTTAAAGAG CATAGAGACA ATGAAAGGCT AAAGAAAATT TTAAAATCTC
TGCCACAGTC TCATAGGTGC TTGGAAATGA AAGTAGAACT GCCTGTCTTT AACGGACTCT GACAGAGAGG
GTGAAGGGGA ACCAGAGCGC ACAAGGGAAC TGACTCAGGA GGCAGAGAAG ATGGGCATCC TCAGCGTAGA
CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC AACTGCCTCT TCCTGGCTCT CTATGACTCG
GTCATTCTGC TCAAGCACGT GGTGCTGCTG TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA
TGCTGACCTC AGAGGGACTG CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT
GGGTGAGGAT GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT GAGCGCCCAC
TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG CCAGCCTTCC GCAAACTGGT
GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC ATTGATGAGG CTCATCCATC AGATGGCTGG
GCGATACCGG GGGACTCCTC TTTGTCTTTT GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG
CAGCCCAGCA GCTTCTGGAG CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA
TAACGCCAAC ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG AATTTCAGCA
AGAGATGAAA GAAAACTAGA TTAGCTGGTT AAAGGTATGA TTATAAGAGA GCTTATTGTT TTAAAAAGTT
ATATAAAGGC AAGGAAATTA AGAACTGAAT CCATATTTCA ACAGAGCCCT ATTGGCTTAC TGAAAGACAG
GAGTTTATCT ATCGGAAGAA CATGAATCTC TAACAGCTCC ATACTTCTTT CACTACTCAA ATGGCATTGG
GCTGAGTAAG TAACCATATC ACCTCTCTTC TTAGTAAAAA GCCCTATGTG AAAAGATCCC AAGATGGAGA
GGAAGAAACG CTAATTCAGC ATGTGTTCAT TCTGCATTGA GAAGGAACTG ATACATCTGA TGCATGCTTT
GAGACCAGAA GAAAAGACTT ACCTGAATAA TTACTACATT AGGGAAGCTA CTGTCTACGT TAAGATAAAG
GGTATTGCCT TGGCTCTATT TGGCATGGAT GGAGCCCAGT TGGAAAATTC CCAAATATTA CAACAAGTCC
TTGAACCCAG GCCATGTGGT TAGACGTTGG TGTTAAGGTT AGACCTTATG TTAGAGTCAT TTCTGATGTT
CCAGCTTCTA GCCATGTAGT GCTCTCAGTC TTCATACCCC AGAAATTATT GGTATATTTG TAGATACCGA
GAATGATCCC TCAGTCTGAG AGGTTAGAAT GATCATCTGT AATCTGAGGG TTAATTTCTA GGCAGGTGGA
GAGAGTGGTA AAAAAGAAAT GAAATTGACA AGCTAGGAAA GAGGAGGCAG AAAGATTTGG AAAATTCACA
GAGTTTCACC CTTAAGCTGT AGAGAGTGGG TCACATTTGT TAGCCACGGA AACATAGAAA CATACACAAG
GCCAGAAAAA GAAGAAGGAG CTCAACTAAA AGTGGCATAG AGAATACACA TATAAAAACA ATATATTTGT
CATATGCTCC TAGAGAGGAG AAAGGGGTGA TTGAAAGAAA AAAAAATACT TAAATATTTG TAATTGTGAG
GGGTTTCTTT TGGAAATAAT TACTTTTGAA CCATGTATGT GGTATGTATA TTTTCAGTGG GTTAATTATA
CCCCATGATA CCTATTAAAG GAAAACCAGT GGGTCTGGTG GTGCTGGTCT TTTCCTCCCC ATTCCTACAA
TTTCTATGTG GCCCAAGTCA TTCCTAATCT TGGTCTCTAT AGCAGTGTTC TCTCTGAATG CTGAGCTGAA
GAAATTATAC GTACATACAC ACATACATAC ATACATACAA ATATATGTAT ATATATTCTC AGCTGCTGCG
GGAGGTAGGT ACCATGGCCA TTCAGCACAG CCTTGATTTC CTCCCAAAGT AGGTGAGCTA TAGTGAAGAA
TAGGTGCAAA CAAACAAGCT TACTTCCATT GCAAAATAGA AGAAGAGGAA GTTAGAGATA ATTCTGATCA
ATCATTTTGG AGGCTTTGTT ATAAGGCAAC CCCCGGTATA TCATGGAATT TCCATTGACA TTTGAATTTG
GACTTGGATC TTCCCTTGGT CCCATTAGCT GAGGTTTAGT AATCTAAAGT CCCTATAGTA TATGATTATA
ATGCTATTTT AAAAAATATA TATATAAAAT ATTTTTTTCT TTTTAAAATA GACACTATAG TTTTACCCAT
AAGTAATATT TAAAGATTAT AGCTCCCAAA AGAATGGACC AACCACTTTC GTATCATAAT TTCTTTTTGG
TAAATATGAG ACTATTATGA AATCATAGTA TATGATTGTA TTTAAAGGTA CAATCAAAGG ATCTTTTGTC
CATTCCATTA ATAACTGAAT AAAAAATAAA TAAAATGGAT AGAAAAAAAC TAAAGTTGAA AATACATTCT
TAAACTAGTT GTCTGAAATG AGAAAAGAGT GAGAACTAGG TGTGCAAGAA CCAAACGTAT TTTATTTTAT
TTTTTAAATG GGAGCAACAT ATCAGTCGTG TCACCAGCTG GTATATTGTG TAAATATTAA AGCTCCATTG
GGACTGATTT TTCATGGCAA CATCAGCTTT CTAATGTTCT AAATTCTATA AAAACCACCC ACAAAGAAAC
AAAGCAAATT TCATTATCTA ATGAGTTGCT GGAAAATCAT ATTGAGAATA ATTATTTCAG ATTCCTCAGT
TGTTAACTTC TACATTCAAG GGCTTATCTC TGCCCCCATT GATTTTTAAC CTCAAAATGG TGTGAGATTT
ACTGTGGAAC CCTAAAGCAG TAAAATAAAA AACCTGGTTG CAGCACATTC ACACTGTTGT CCTTAAAATT
CCCCTTTTTT CTCTATGTAC GATAAAGTAA CAGTATGTCA GATAAGCCGG TGGGGGGATG AGATTAGGCT
GAGGCAGTGC TAGTCAACTG GGGGAAAAGG ATGATGGAAA AATCACCCAG TTGTGCTATA TTTTTAAAGA
AGGAGGTCGT TTATGTGTGC AGACAATTCT CCCTGAGGTT AGCCCAATGG AGAAATGAAG CAGAGGAAGG
AAACATAGAA AGACATGGGC TATCAGGGAG GAAGATGTTC AATAGAACAT GCAAGAATTT CTGGAAGAAA
GGCTGTGGAA GGGCCAATGG AGAAAATGAA TGGACAAAGC TCAGGAATCC CTACGCTATG TAGAATGTTC
TTGGTGTTAT CAGGGTTAAG CCCTGTAATT ATGTAACCTA TTTATCGCAA CATGAATTTT TATGATTTCT
TGTGATGTAT TCTTTTATGA AATTAACAAG AACTCATTAT TTTGAGGTAG AGGAAAATCA ATGCTTTATC
TGATATGCTG AGAAATTATT AGATTGCCAA TACTCATGTG CGTTTCATGT GTTTTATAAG GTTTGTTCCT
TTGAAGAATT GTAGTTCTTA GTCCCACAGG GAAATGTGTA TCTATTTATA TATCATAGTA TAAATCTATG
ATATATTTAT ATCATATATA AAAGTCTGAG TTCTCTTTCT TAGTCCCTAA TCATGTTTCT CCCATAGGCT
GTGTTTACAT GGAGCTATCG GTTTAGCCTT TTAAGCTTCA TTAGCTTGTC TATTATTGAA ATAGTTTCCA
AGAAATTTTA GATATTATCA TAACATCTGG GTCTACTCAA ACACTTATTG TTTGAAAGAC TTATGTCTTG
GACCTATCAA AAACTGACTT TATTTATTGC TTAGTGAAAA TACTAGTGGG ATCAACAATG ATTTTCTTGA
ATGGGCATGA ATGGAGATGC CCGCACAGTA ATGTAGAAAT GTTTCATACA GCTATTAAAA TGTAACTGAC
CTCCTTAGAG GCAGATTAGT AACTGTTCCT ACTTTGTATA GCTAAGTGAC AGTCACTTAA CTTACATGAC
TTTCTTTTTT CACATTGGGT CTCTGGTCCT GTGTCTTCAC CTCATTTATA GCACGTCTCC TTGATTTTTG
GTAGTATCAA CTTCCCAGTG ATCTGTTCAG TTAAGTTCTT CTCCCGTTAA CCAGGAAGTG CTTATTCTCT
CATCACAGTG GGAAGAATAG CCTATTGTCT TTCATTTTGC CTGAGTGTAT TTTACTATTT GGGCTCTGAA
ATAAAAATTA TGAAATATGG TGAGGTCACA TGTTGGTGCT GCCTTGCTGC ATAAAATTCT AGGAGGGCAG
GTTAGGAGAC AGTTATGTAT GGCCTTTCGG GAAAATTCAA AGGGTGGGAT TACAAGGGTG TTCCTCAGGC
ATGCCCCTAT GGGCCCTATG TGGAAGCAAG AAGAATTGAC TGATTTACAG GACTTCTCTT TATGTCAATC
TTAAGAGGAT GGATGAATCT GGACATTTGT TCCACCCGAC CTCTGACTGA TGGTTTGGAA AATAACTTTA
ATTAGGATCA TATGACCATT GAAAAAGGAA AAATGTAGAC TCTGACTTCC GTCCCACTGA AGGATTAATG
AAAACCTTTA CTAGCATTTA GAGCTTTTCA GAACATCCCC ACTGTCATGT GTCTCAGCAG TGGAGACTGC
AAGTAAGGCT TTTAATTTTA GGAGGTTTTT TTTTTTTTTT TTTTTTCCCC TAAATGGTAT GGCCAAAAGT
CAGAGTTAAA ATATATATAG TTAGATTCCA ACTTCCTCCT TCACTCTAAA AATAGAATCC AAACCCACTC
TTCATATATG CTTCCAGAAT GGGGCTTAAG TACCAATCTC TGCTTTGCAA TGGGCACAAT CTTGGTCATG
TCCTGAGGCT CTCTAAGAAA AGAGAGGATC TAGGATGGGA GAGCTAGAAA GTTGCTAACT GGGAAGAACA
AGGCCCTGAG GGGTTGGTCT ACCAATCTGG GAAGATTTGA AAACAAACTT CTCGCAACTG AAGGAAGGCT
GAAGGCTGCT GCAAGTCATT GAGTGACTTT AGGATGAGCA AAACATTGGG CCACTTCCTA ATGCCCTATG
TGTATAGTAC CAGAAGCAAG GTCTCAGACT TAACAGACCC AGCTCTGTTC CAAGGTGAGT CTGAACCAAT
AGAAAGCAAA CATGTGCAGA TATCCAAACA AGACTGCTCA TGCAAGTCGG GGCTGGCTAC CCGTCTTAGG
CAGCAACAGC AGAGCTCCAG GGAGCTTATT CAATATTTAC TGAGACTTCG AAGACCCAGC AGATGTTTAA
TGAAGTCACT ATTTTGGCTC AAACCCTCCA CTTCTCCCCC TCCCCTCAAA AAGCCAACAG GTAAACACAT
AAATGAAAGA AACCCACAGA AGGGGATGGG AAATAAAGAA AATTCTCTCA AGACTTCTCC AGGCCCATGT
CACTGGTCAG CGTGGTTTTT ATGTGTATTA GGATTGGGGG ATGTGAAGAA ATAAGTATCC AGTACTTTAT
AACCAAAGCA ATTAAATGAT ATTGGGGTAG GGAATGTTGG CCAGTTTTGT TTAGTTTTGC CATCACATTG
TCACCCAGAC CTCACCTAGC CCCAAGTAAT CGGGCGCCCC GAAGAGGGAG ACAGAGATGT GCCAGAGTTG
ACCCAGTGTG CGGATGATAA CTACTGACGA AAGAGTCATC GACCTCAGTT AGTGGTTGGA TGTAGTCACA
TTAGTTTGCC TCTCCCCATC TTTGTCTCCC TGGCAAGGAG AATATGCGGG ACATGATGCT AAGAGCCCTG
GGTAAATGTG GTGAGAATGC ACGCGTGCAT ATGCTACACA TATGTGCTTC TCAGTTGCAG AAAATGAACT
GCTTTGGGAG ATTATCAGTA GAAAGAGTGT TATCATATTG GTGCTGAGTG CTATGTGTGC TTATACAATT
TGTTCTTGTA TTTTAATAAA CTTTGAATAA AAGAATAAAA AAAAAAAAAA AAAAAAAA
Product
| Product | dio2 |
| Description | type II iodothyronine deiodinase (DIO2); catalyzes the 5'-deiodination of thyroxine (T4, prohormone) to form 3,5,3'-triiodothyronine (T3, active hormone) |
| Modifications | 797..799,aa:Sec|1196..1198,aa:Sec |
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL RCVWKSFLLD
AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP ERPLVVNFGS ATUPPFTSQL
PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF EVKKHQNQED RCAAAQQLLE RFSLPPQCRV
VADRMDNNAN IAYGVAFERV CIVQRQKIAY LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG
Publications
- Buettner C, Harney JW, Larsen PR. (1998) The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element. J Biol Chem. 273(50):33374-33378. [abstract]
- Bartha T, Kim SW, Salvatore D, Gereben B, Tu HM, Harney JW, Rudas P, Larsen PR. (2000) Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology. 141(1):229-237. [abstract]