Recode v. 2.0 / Database of translational recoding events.
Details for "r200320"
| Accession number | r200320 [export] |
| Locus name | selP |
| Recode1 name | selP_s_euk_hsap |
| Description | selenoprotein P |
| Recode status | Reviewed |
Organism
| Genomic class | Eukaryota (Chromosome) |
| Organism | Homo sapiens [details] |
Sequence
| GenBank IDs | NM_005410.1,Z11793.1 |
| Sequence | mRNA of 2038 nucleotides [sequence] |
| Organisation | SECIS structure (2)
|
Recoding event
| Event type | Selenocysteine (positions: 211, 934, 988, 1024, 1069, 1090, 1135, 1141, 1162, 1168) |
| Description | Selenocysteine incorporation. mRNA contains 10 UGA codons, each of which can be translated as selenocysteine; efficiency of Sec incorporation at each UGA in selP mRNA appears to be different which results in multiple product forms; in particular, the second in frame UGA dictates significant termination giving rise to selenoprotein which may have a separate function. 3'UTR contains 2 SECIS elements. |
GCAGGCCCGT TGGAAGTGGT TGTGACAACC CCAGCAATGT GGAGAAGCCT GGGGCTTGCC CTGGCTCTCT
GTCTCCTCCC ATCGGGAGGA ACAGAGAGCC AGGACCAAAG CTCCTTATGT AAGCAACCCC CAGCCTGGAG
CATAAGAGAT CAAGATCCAA TGCTAAACTC CAATGGTTCA GTGACTGTGG TTGCTCTTCT TCAAGCCAGC
TGATACCTGT GCATCATCGA GGCATCTAAA TTAGAAGACC TGCGAGTAAA ACTGAAGAAA GAAGGATATT
CTAATATTTC TTATATTGTT GTTAATCATC AAGGAATCTC TTCTCGATTA AAATACACAC ATCTTAAGAA
TAAGGTTTCA GAGCATATTC CTGTTTATCA ACAAGAAGAA AACCAAACAG ATGTCTGGAC TCTTTTAAAT
GGAAGCAAAG ATGACTTCCT CATATATGAT AGATGTGGCC GTCTTGTATA TCATCTTGGT TTGCCTTTTT
CCTTCCTAAC TTTCCCATAT GTAGAAGAAG CCATTAAGAT TGCTTACTGT GAAAAGAAAT GTGGAAACTG
CTCTCTCACG ACTCTCAAAG ATGAAGACTT TTGTAAACGT GTATCTTTGG CTACTGTGGA TAAAACAGTT
GAAACTCCAT CGCCTCATTA CCATCATGAG CATCATCACA ATCATGGACA TCAGCACCTT GGCAGCAGTG
AGCTTTCAGA GAATCAGCAA CCAGGAGCAC CAAATGCTCC TACTCATCCT GCTCCTCCAG GCCTTCATCA
CCACCATAAG CACAAGGGTC AGCATAGGCA GGGTCACCCA GAGAACCGAG ATATGCCAGC AAGTGAAGAT
TTACAAGATT TACAAAAGAA GCTCTGTCGA AAGAGATGTA TAAATCAATT ACTCTGTAAA TTGCCCACAG
ATTCAGAGTT GGCTCCTAGG AGCTGATGCT GCCATTGTCG ACATCTGATA TTTGAAAAAA CAGGGTCTGC
AATCACCTGA CAGTGTAAAG AAAACCTCCC ATCTTTATGT AGCTGACAGG GACTTCGGGC AGAGGAGAAC
ATAACTGAAT CTTGTCAGTG ACGTTTGCCT CCAGCTGCCT GACAAATAAG TCAGCAGCTT ATACCCACAG
AAGCCAGTGC CAGTTGACGC TGAAAGAATC AGGCAAAAAA GTGAGAATGA CCTTCAAACT AAATATTTAA
AATAGGACAT ACTCCCCAAT TTAGTCTAGA CACAATTTCA TTTCCAGCAT TTTTATAAAC TACCAAATTA
GTGAACCAAA AATAGAAATT AGATTTGTGC AAACATGGAG AAATCTACTG AATTGGCTTC CAGATTTTAA
ATTTTATGTC ATAGAAATAT TGACTCAAAC CATATTTTTT ATGATGGAGC AACTGAAAGG TGATTGCAGC
TTTTGGTTAA TATGTCTTTT TTTTTCTTTT TCCAGTGTTC TATTTGCTTT AATGAGAATA GAAACGTAAA
CTATGACCTA GGGGTTTTCT GTTGGATAAT TAGCAGTTTA GAATGGAGGA AGAACAACAA AGACATGCTT
TCCATTTTTT CCTTTACTTA TCTCTCAAAA CAATATTACT TTGTCTTTTC AATCTTCTAC TTTTAACTAA
TAAAATAAGT GGATTTTGTA TTTTAAGATC CAGAAATACT TAACACGTGA ATATTTTGCT AAAAAAGCAT
ATATAACTAT TTTAAATATC CATTTATCTT TTGTATATCT AAGACTCATC CTGATTTTTA CTATCACACA
TGAATAAAGG CCTTTGTATC TTTCTTTCTC TAATGTTGTA TCATACTCTT CTAAAACTTG AGTGGCTGTC
TTAAAAGATA TAAGGGGAAA GATAATATTG TCTGTCTCTA TATTGCTTAG TAAGTATTTC CATAGTCAAT
GATGGTTTAA TAGGTAAACC AAACCCTATA AACCTGACCT CCTTTATGGT TAATACTATT AAGCAAGAAT
GCAGTACAGA ATTGGATACA GTACGGATTT GTCCAAATAA ATTCAATAAA AACCTTAAAA AAAAAAAAAA
AAAAAAAA
Product
| Product | selP |
| Description | selenoprotein P, antioxidant? selenium storage (or transport)? |
| Modifications | 211..213,aa:Sec|934..936,aa:Sec|988..990,aa:Sec|1024..1026,aa:Sec|1069..1071,aa:Sec|1090..1092,aa:Sec|1135..1137,aa:Sec|1141..1143,aa:Sec|1162..1164,aa:Sec|1168..1170,aa:Sec |
MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT VVALLQASUY LCIIEASKLE
DLRVKLKKEG YSNISYIVVN HQGISSRLKY THLKNKVSEH IPVYQQEENQ TDVWTLLNGS KDDFLIYDRC
GRLVYHLGLP FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL KDEDFCKRVS LATVDKTVET PSPHYHHEHH
HNHGHQHLGS SELSENQQPG APNAPTHPAP PGLHHHHKHK GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR
CINQLLCKLP TDSELAPRSU CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA
AUQISQQLIP TEASASURUK NQAKKUEUPS N
Publications
- Grundner-Culemann E, Martin GW, Harney JW, Berry MJ. (1999) Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes. RNA. 5(5):625-635. [abstract]
- Chittum HS, Himeno S, Hill KE, Burk RF. (1996) Multiple forms of selenoprotein P in rat plasma. Arch Biochem Biophys. 325(1):124-128. [abstract]
- Himeno S, Chittum HS, Burk RF. (1996) Isoforms of selenoprotein P in rat plasma. Evidence for a full-length form and another form that terminates at the second UGA in the open reading frame. J Biol Chem. 271(26):15769-15775. [abstract]
- Hill KE, Lloyd RS, Yang JG, Read R, Burk RF. (1991) The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. J Biol Chem. 266(16):10050-10053. [abstract]