Recode v. 2.0 / Database of translational recoding events.
Details for "r200344"
| Accession number | r200344 [export] |
| Locus name | trr3 (TR3; TrxR3) |
| Recode1 name | trr3_s_euk_hsap |
| Description | thioredoxin reductase |
| Recode status | Validated |
Organism
| Genomic class | Eukaryota (Chromosome) |
| Organism | Homo sapiens [details] |
Sequence
Recoding event
| Event type | Selenocysteine (position: 1732) |
| Description | Selenocysteine incorporation at UGA codon. sequence incomplete; translational start site is missing; Sun,Q.A. et al called this sequence TR2; SECIS element is unidentified |
GCAGAGCGGG TGGTGATCTT CAGCAAGAGC TACTGTCCCC ATAGTACTCG GGTGAAAGAA CTCTTTTCTT
CTTTGGGAGT CGAATGTAAT GTCTTGGAAC TTGATCAAGT TGATGATGGG GCCAGGGTTC AAGAAGTGCT
GTCAGAAATC ACTAATCAGA AAACTGTGCC CAATATTTTC GTGAATAAAG TGCATGTAGG TGGATGTGAC
CAAACTTTCC AGGCATATCA GAGTGGTTTG TTACAGAAGC TCCTTCAGGA AGATTTGGCA TATGATTATG
ATCTCATCAT CATCGGTGGT GGTTCTGGAG GCCTTTCATG TGCGAAGGAA GCTGCCATTT TGGGAAAGAA
AGTTATGGTG CTAGACTTTG TTGTCCCGTC ACCTCAGGGC ACATCCTGGG GTCTTGGTGG CACTTGTGTA
AATGTAGGTT GTATTCCTAA GAAATTGATG CATCAGGCTG CCCTTTTGGG GCAGGCATTA TGTGACTCAA
GGAAATTTGG CTGGGAATAT AATCAACAAG TGAGGCACAA CTGGGAGACA ATGACAAAAG CGATTCAGAA
CCACATCAGC TCTCTAAACT GGGGCTACAG GTTGTCTCTG AGGGAAAAGG CTGTGGCCTA TGTCAATTCC
TATGGAGAAT TTGTTGAACA TCATAAAATA AAGGCAACCA ATAAAAAAGG ACAGGAGACT TATTATACTG
CTGCACAGTT TGTCATAGCA ACGGGTGAAA GGCCACGGTA TTTAGGAATC CAAGGAGATA AAGAATACTG
TATTACTAGT GATGACCTTT TTTCTCTGCC TTATTGCCCT GGCAAAACAT TAGTGGTGGG TGCCTCTTAT
GTTGCCCTGG AGTGTGCAGG GTTTCTGGCT GGCTTTGGCC TAGATGTCAC AGTTATGGTA CGCTCAATCC
TTCTCCGTGG CTTCGACCAA GAAATGGCAG AAAAAGTGGG TTCCTACATG GAGCAGCATG GTGTGAAGTT
CCTACGGAAA TTCATACCTG TGATGGTTCA ACAGTTGGAG AAAGGTTCAC CTGGAAAGCT GAAAGTGTTG
GCTAAATCCA CTGAAGGAAC AGAAACAATT GAAGGAGTCT ATAACACAGT TTTGTTAGCT ATTGGTCGTG
ACTCCTGTAC AAGGAAAATA GGCTTGGAGA AGATTGGTGT CAAAATTAAT GAGAAGAGTG GAAAAATACC
TGTAAATGAT GTGGAACAGA CCAATGTGCC ATATGTCTAT GCTGTTGGTG ATATTTTGGA GGATAAGCCA
GAGCTCACTC CTGTCGCCAT ACAGTCAGGC AAGCTGCTAG CTCAGAGACT TTTTGGGGCC TCTTTAGAAA
AGTGTGATTA TATTAATGTT CCGACTACAG TGTTTACTCC TCTGGAGTAT GGTTGCTGTG GATTATCTGA
AGAGAAAGCT ATTGAAGTAT ATAAAAAAGA GAATCTAGAA ATATATCATA CTTTGTTCTG GCCTCTTGAA
TGGACAGTAG CTGGCAGAGA GAACAACACT TGTTACGCAA AGATAATCTG CAATAAATTC GACCATGATC
GGGTGATAGG ATTTCATATT CTTGGACCAA ACGCCGGTGA GGTTACCCAA GGATTTGCAG CTGCAATGAA
ATGTGGGCTC ACAAAACAGC TACTTGATGA CACCATTGGA ATTCACCCCA CATGTGGGGA GGTGTTCACG
ACTTTGGAAA TCACAAAGTC GTCAGGACTA GACATCACTC AGAAAGGCTG CTGAGGCTAG GCCTGCTGCT
GTTTAGTTCT CCTTGTCATA TTCTCATTTC TCTCAAAGAT AAGAATGCTC TCGGATAAAA TGAGCCTGTG
CTCATGACAG CTGCTCTGTT ACTCAGGGAC CAGTGCAGGG CTGTCTTACG ACACTTAGAT GAGAAAGTAG
ACAAGGAAAG AGGACAGCAG TGGGCATCTG CCTTGTGGTC TTGCTGACAG CGAGAAGCAG TGGGACTGCT
TCCTTGACGC CTTAGCTTGG AGCCCCGTTA TGAGGTGAGC CAAGGCTGAC TCTCGCAAGC CAGGACTGAG
CTTCCCTCGG AAAGACCTTT GAGTGGCACC ATTCACCTAA GTTAGCTTTT CTGGTCGCTA TTGTTTTTAT
CCCCTTTGCT TTGTTGTTTC TGTGAAAATA TATTTTCAGT TAAGAAATGC TATAAAGTAG TGGTTTTCTA
GTGCGTGGGC CTAGAATTCA CACATGCTCA CTGGTGAACA GTGTCTGTGG GCTGCTGTGG GCTGCATTTG
GATAGCTGTC TGCATTAGCA GGAAGCTGTA CACACTGTGT AGGGTTAGTC ATCTCTTTTC TTTTTTGAGG
CACATTTAAC CTACTGTCAA AACGCTGACT CATGCTTCAC CCTCACACTC ACTACTTGGT GGTGATAACC
TTGAAGCTAT TCTCCCCTAA TTAATATCTC GAGACTGAGC AAAATATCTC ATGTAAGATA AAAGTACTTG
AATTGCTTTT TCATGTTCAT CTTAATAGTA TTATTTCCAA AAGTTTTTAA TACTGTATTA TGTGAAATCT
AACTAATTTA TCTGTGAAAT AATTCCATCA CAGTCTGTTT AATGATGATA AAGTTCCATA AATGAATACA
GGT
Product
| Product | trr3 |
| Description | thioredoxin reductase 3; NADPH-dependent reduction of thioredoxin |
| Modifications | 1732..1734,aa:Sec |
AERVVIFSKS YCPHSTRVKE LFSSLGVECN VLELDQVDDG ARVQEVLSEI TNQKTVPNIF VNKVHVGGCD
QTFQAYQSGL LQKLLQEDLA YDYDLIIIGG GSGGLSCAKE AAILGKKVMV LDFVVPSPQG TSWGLGGTCV
NVGCIPKKLM HQAALLGQAL CDSRKFGWEY NQQVRHNWET MTKAIQNHIS SLNWGYRLSL REKAVAYVNS
YGEFVEHHKI KATNKKGQET YYTAAQFVIA TGERPRYLGI QGDKEYCITS DDLFSLPYCP GKTLVVGASY
VALECAGFLA GFGLDVTVMV RSILLRGFDQ EMAEKVGSYM EQHGVKFLRK FIPVMVQQLE KGSPGKLKVL
AKSTEGTETI EGVYNTVLLA IGRDSCTRKI GLEKIGVKIN EKSGKIPVND VEQTNVPYVY AVGDILEDKP
ELTPVAIQSG KLLAQRLFGA SLEKCDYINV PTTVFTPLEY GCCGLSEEKA IEVYKKENLE IYHTLFWPLE
WTVAGRENNT CYAKIICNKF DHDRVIGFHI LGPNAGEVTQ GFAAAMKCGL TKQLLDDTIG IHPTCGEVFT
TLEITKSSGL DITQKGCUG
Publications
- Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN. (1999) Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 274(35):24522-24530. [abstract]
- Miranda-Vizuete A, Damdimopoulos AE, Pedrajas JR, Gustafsson JA, Spyrou G. (1999) Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization. Eur J Biochem. 261(2):405-412. [abstract]