Recode v. 2.0 / Database of translational recoding events.
Details for "r200351"
| Accession number | r200351 [export] |
| Locus name | OAZ1 |
| Recode1 name | oaz1_p_euk_hsap |
| Description | Ornithine decarboxylase antizyme OAZ1 |
| Recode status | Validated |
Organism
| Genomic class | Eukaryota (Chromosome) |
| Organism | Homo sapiens [details] |
Sequence
| GenBank IDs | D78361.1,BU682873.1,BG476870.1,BF792874.1,BX365773.2,BX374201.2,BI117708.1,AL552947.3,BI160800.1,AW001575.1,BI085895.1,BI084796.1 |
| Sequence | mRNA of 1063 nucleotides [sequence] |
| Organisation | Pseudoknot (1) [see structure]
|
Recoding event
| Event type | +1 Frameshifting (position: 349) |
| Description | Efficiency of ODC antizyme biosynthesis is modulated by polyamine levels; sensor for an autoregulatory circuit |
CGAAGCGGAG TGAGAAGGAC GGTCCCGTTC GTCACGAACG TCCGTCCCTC GTCCGTCGCG GCTCGGACCC
GGTCCGGGAG AGCAGTGGCG GTGGTGCGGA GAGACGCAGC GGAGGTTTTC CTGGTTTCGG ACCCCAGCGG
CCGGATGGTG AAATCCTCCC TGCAGCGGAT CCTCAATAGC CACTGCTTCG CCAGAGAGAA GGAAGGGGAT
AAACCCAGCG CCACCATCCA CGCCAGCCGC ACCATGCCGC TCCTAAGCCT GCACAGCCGC GGCGGCAGCA
GCAGTGAGAG TTCCAGGGTC TCCCTCCACT GCTGTAGTAA CCCGGGTCCG GGGCCTCGGT GGTGCTCCTG
ATGCCCCTCA CCCACCCCTG AAGATCCCAG GTGGGCGAGG GAATAGTCAG AGGGATCACA ATCTTTCAGC
TAACTTATTC TACTCCGATG ATCGGCTGAA TGTAACAGAG GAACTAACGT CCAACGACAA GACGAGGATT
CTCAACGTCC AGTCCAGGCT CACAGACGCC AAACGCATTA ACTGGCGAAC AGTGCTGAGT GGCGGCAGCC
TCTACATCGA GATCCCGGGC GGCGCGCTGC CCGAGGGGAG CAAGGACAGC TTTGCAGTTC TCCTGGAGTT
CGCTGAGGAG CAGCTGCGAG CCGACCATGT CTTCATTTGC TTCCACAAGA ACCGCGAGGA CAGAGCCGCC
TTGCTCCGAA CCTTCAGCTT TTTGGGCTTT GAGATTGTGA GACCGGGGCA TCCCCTTGTC CCCAAGAGAC
CCGACGCTTG CTTCATGGCC TACACGTTCG AGAGAGAGTC TTCGGGAGAG GAGGAGGAGT AGGGCCGCCT
CGGGGCTGGG CATCCGGCCC CTGGGGCCAC CCCTTGTCAG CCGGGTGGGT AGGAACCGTA GACTCGCTCA
TCTCGCCTGG GTTTGTCCGC ATGTTGTAAT CGTGCAAATA AACGCTCACT CCGAATTAGC GGTGTATTTC
TTGAAGTTTA ATATTGTGTT TGTGATACTG AAGTATTTGC TTTAATTCTA AATAAAAATT TATATTTTAC
AATTTTATTC CGG
Product
| Product | oaz1 |
| Description | ODC antizyme:1. Inhibition and targeting ODC for degradation; 2.Regulation of polyamine transport |
| Modifications | 348..350:ribosomal_frameshift |
MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS RVSLHCCSNP GPGPRWCSDA
PHPPLKIPGG RGNSQRDHNL SANLFYSDDR LNVTEELTSN DKTRILNVQS RLTDAKRINW RTVLSGGSLY
IEIPGGALPE GSKDSFAVLL EFAEEQLRAD HVFICFHKNR EDRAALLRTF SFLGFEIVRP GHPLVPKRPD
ACFMAYTFER ESSGEEE
Publications
- Ivanov IP, Matsufuji S, Murakami Y, Gesteland RF, Atkins JF. (2000) Conservation of polyamine regulation by translational frameshifting from yeast to mammals. EMBO J. 19(8):1907-1917. [abstract]
- Tewari DS, Qian Y, Thornton RD, Pieringer J, Taub R, Mochan E, Tewari M. (1994) Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. Biochim Biophys Acta. 1209(2):293-295. [abstract]
- Yang D, Takii T, Hayashi H, Itoh S, Hayashi M, Onozaki K. (1996) Molcecular cloning of human antizyme cDNA. Biochem Mol Biol Int. 38(5):957-964. [abstract]
- Bekaert M, Ivanov IP, Atkins JF, Baranov PV. (2008) Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs. BMC Bioinformatics. 9(178). [abstract]