Recode v. 2.0 / Database of translational recoding events.

 

Details for "r200424"

Accession numberr200424 [export]
Locus namedio3
Recode1 namedio3_s_euk_mmus
Descriptioniodothyronine deiodinase
Recode statusValidated

Organism

Genomic classEukaryota (Chromosome)
OrganismMus musculus [details]

Sequence

GenBank IDsNM_172119.1,AF426023.1
SequencemRNA of 1863 nucleotides [sequence]
OrganisationSECIS (1) [see structure]

Recoding event

Event typeSelenocysteine (position: 507)
Descriptionselenocysteine incorporation.
TGCCTCGCCA GGCCGCCTCG AGGTTGGTGG TCGGAGAAGG TGAAGGGCCC CCGGGGGCTT CGGGGCCCGC GGCCACCATG CTCCGCTCTC TGCTGCTTCA CTCGCTGAGG CTCTGCGCCC AGACCGCCTC GTGCCTCGTG CTGTTCCCGC GCTTCCTAGG CACGGCCTTC ATGCTCTGGC TTTTAGATTT CTTGTGCATC CGCAAGCATT TCCTGCGCCG TCGCCATCCT GACCACCCTG AGCCCGAAGT AGAGCTCAAC AGTGAAGGCG AGGAGATGCC CCCTGACGAC CCGCCCATAT GCGTATCAGA CGACAACCGT CTGTGCACCC TGGCCTCTCT CAAAGCCGTG TGGCATGGCC AGAAATTGGA TTTCTTCAAG CAAGCCCATG AGGGTGGCCC AGCGCCCAAC TCGGAGGTTG TCCGACCTGA TGGCTTCCAG AGCCAGCGCA TCCTCGACTA CGCACAAGGG ACCCGCCCGT TGGTGCTCAA TTTTGGCAGC TGTACCTGAC CACCGTTCAT GGCGCGGATG AGCGCCTTCC AGCGCCTGGT CACCAAGTAC CAGCGCGACG TTGACTTCCT TATCATCTAC ATCGAGGAAG CCCACCCATC CGACGGCTGG GTCACCACAG ATTCACCCTA TGTCATCCCC CAGCACCGCA GCCTGGAGGA CCGTGTCAGC GCAGCGAGAG TACTACAACA AGGTGCACCT GGCTGTGCTC TGGTCCTGGA CACTATGGCC AACTCTAGCA GTTCCGCATA TGGTGCCTAT TTTGAGCGCC TCTACGTCAT CCAGAGTGGC ACCATCATGT ACCAGGGAGG CCGTGGCCCC GACGGTTACC AGGTGTCTGA GTTGCGCACT TGGTTGGAGC GCTATGATGA ACAGTTGCAT GGTACTAGGC CACATCGATT CTAAATAACC AAGGGACAAG TGACTGAATT GGTGGGCCGG GTCTCCTGGG CCTTCGAAGC CCACGTGCAA ATGCTCCAAA GAAAGTCAAA GGTTGTGGGG GATCCCCATG ACACAGATGA GCACAGCCAC AGAACTCAGG CTGAGTCTGG CTAACTTGAG ACTCTGCTAT AGTGACTCCC TTTTGTACGT TTTTGGCTTG CTCTCAGGAG CATTGCTGTG GCTCGAACTG ACAGCTTTGT CCCTGCTGGA GTTTACCTGC TGGACTTTCT GACACCAGGT CTCCAGCGCT GCTTCGGCAA AGCGCGAAAG TCCCCAGCAT TTCACAGCTC GGACTTGTTG GCCACGCCCG CGCGCCCTGA GCGCAGCTGG GTTCCAGCAG CGCCTCAGGC TCTAGCTAGT TGCCTGGCAC CCACCTGTCG AGCGCAGGGA GTCCTGCTGC TTTTGTGTTT ATTTCTTATC CCTGGGTTGG GGGAGGGGCT CGAGATAGGG AAAGGGTGGG CAGGGTAATT TCCCCGCCTA GCTTTGGGTG CGCTGGAGCC CTGGCTGCTG ATGACGAACC GCCTCTAACT GGGCTTGACC ACGGGTCGGC TCTGAATTGC AGAGAGGCTC GAAACAGCGC CTAAAGTAAG AGGGGGAGAG TGCTCTGGGT TCCACAGGGA ACCGTCGAAA AAGGGGTGGA AGAGGGACAT GGTAAGGGAT GGACTTCGAG ACCAAAGGAA GTGGCTTGGG GAATCAATCT GCGAGGTTCG CAGGTCCCCA GGAGGGATGC GAGAACTTTT TGGAGAAGGG ATTAGTTCTA AGACAAGGAG AAGGGGAAGA ACTTGGGAGT CCTAGGCAGA AAGCGCGGGT TGTGGGGCGG GGTGAAAACC AATCAGTGAA TGTTGTGTTG GAAACATTCC TTGTGTATAA ACTTTTAAGC TACAATAATA AAGACTTGAA GGAAGTTGCT CTG

Product

Productdio3
Descriptiontype III iodothyronine deiodinase (DIO3), inactivates thyroxine (T4, prohormone) and 3,5,3'-triiodothyronine (T3 active hormone) by 5 deiodination forming 3,5',3'-triiodothyronine (rT3) and 3,3'-diiodothyronine (T2) respectively.
Modifications507..509,aa:Sec
MLRSLLLHSL RLCAQTASCL VLFPRFLGTA FMLWLLDFLC IRKHFLRRRH PDHPEPEVEL NSEGEEMPPD DPPICVSDDN RLCTLASLKA VWHGQKLDFF KQAHEGGPAP NSEVVRPDGF QSQRILDYAQ GTRPLVLNFG SCTUPPFMAR MSAFQRLVTK YQRDVDFLII YIEEAHPSDG WVTTDSPYVI PQHRSLEDRV SAARVLQQGA PGCALVLDTM ANSSSSAYGA YFERLYVIQS GTIMYQGGRG PDGYQVSELR TWLERYDEQL HGTRPHRF

Publication